On Guy's Chance of a Lifetime, Guy Fieri searches for one talented food entrepreneur to run their own Chicken Guy franchise but the candidates must prove that they can successfully lead every aspect of the food business from culinary, to marketing and to front of house hospitality.

Over the course of six hour-long episodes, only one will have their destiny changed forever when they win the ultimate chance of a lifetime. To up the difficulty of the interviews, Fieri and his business partner Robert Earl hand selected a panel of experts consisting of business and food professionals (Maneet Chauhan, Hunter Fieri, Hoy Fong, Antonia Lofaso, Christian Petroni & John Thall) to help mentor the candidates each week and determine the winner. Premiered on the Food Network in 2022.